期刊
BIOPOLYMERS
卷 106, 期 6, 页码 796-805出版社
WILEY
DOI: 10.1002/bip.22914
关键词
cyclic peptides; cyclotides; kalata B1; natural products; Viola plants
资金
- Thailand Research Fund through the Royal Golden Jubilee PhD Program [PHD/0013/2552]
- Bruker
- National Health and Medical Research Council [APP1028509]
- Australian Research Council (ARC) [DP150100443]
Cyclotides are cyclic peptides from plants in the Violaceae, Rubiaceae, Fabaceae, Cucurbitaceae, and Solanaceae families. They are sparsely distributed in most of these families, but appear to be ubiquitous in the Violaceae, having been found in every plant so far screened from this family. However, not all geographic regions have been examined and here we report the discovery of cyclotides from a Viola species from South-East Asia. Two novel cyclotides (Visu 1 and Visu 2) and two known cyclotides (kalata S and kalata B1) were identified in V. sumatrana. NMR studies revealed that kalata S and kalata B1 had similar secondary structures. Their biological activities were determined in cytotoxicity assays; both had similar cytotoxic activity and were more toxic to U87 cells compared with other cell lines. Overall, the study strongly supports the ubiquity of cyclotides in the Violaceae and adds to our understanding of their distribution and cytotoxic activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据