相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。A proof-of-concept, Phase 2 clinical trial of the gastrointestinal safety of a hydrogen sulfide-releasing anti-inflammatory drug
John L. Wallace et al.
BRITISH JOURNAL OF PHARMACOLOGY (2020)
ZYZ-803, a novel hydrogen sulfide-nitric oxide conjugated donor, promotes angiogenesis via cross-talk between STAT3 and CaMKII
Ying Xiong et al.
ACTA PHARMACOLOGICA SINICA (2020)
The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells
Catherine H. Kaschula et al.
BMC CANCER (2019)
Effects of sulfane sulfur content in benzyl polysulfides on thiol-triggered H2S release and cell proliferation
Sarah G. Bolton et al.
FREE RADICAL BIOLOGY AND MEDICINE (2019)
S-Alk(en)ylcysteine sulfoxides in the genus Allium: proposed biosynthesis, chemical conversion, and bioactivities
Naoko Yoshimoto et al.
JOURNAL OF EXPERIMENTAL BOTANY (2019)
ZYZ-803 Mitigates Endoplasmic Reticulum Stress-Related Necroptosis after Acute Myocardial Infarction through Downregulating the RIP3-CaMKII Signaling Pathway
Lingling Chang et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)
Antibacterial Effect of (2E,2E)-4,4-Trisulfanediylbis(but-2-enoic acid) against Staphylococcus aureus
Tao Wu et al.
PLOS ONE (2018)
Garlic and Gaseous Mediators
Peter Rose et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2018)
Novel H2S-NO hybrid molecule (ZYZ-803) promoted synergistic effects against heart failure
Dan Wu et al.
REDOX BIOLOGY (2018)
A Comparison of the Antibacterial and Antifungal Activities of Thiosulfinate Analogues of Allicin
Roman Leontiev et al.
SCIENTIFIC REPORTS (2018)
Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca2+ /calmodulin-dependent protein kinase II
Dan Wu et al.
REDOX BIOLOGY (2018)
Diallyl Trisulfide Suppresses the Production of Lipopolysaccharide-induced Inflammatory Mediators in BV2 Microglia by Decreasing the NF-κB Pathway Activity Associated With Toll-like Receptor 4 and CXCL12/CXCR4 Pathway Blockade
Hye Hyeon Lee et al.
JOURNAL OF CANCER PREVENTION (2018)
The Effect of Kyolic Aged Garlic Extract on Gut Microbiota, Inflammation, and Cardiovascular Markers in Hypertensives: The GarGIC Trial
Karin Riad et al.
FRONTIERS IN NUTRITION (2018)
H2S biosynthesis and catabolism: new insights from molecular studies
Peter Rose et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2017)
Disulfide Bond-Containing Ajoene Analogues As Novel Quorum Sensing Inhibitors of Pseudomonas aeruginosa
July Fong et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Evaluation of garlic oil in nano-emulsified form: Optimization and its efficacy in high-fat diet induced dyslipidemia in Wistar rats
Gokulakannan Ragavan et al.
FOOD AND CHEMICAL TOXICOLOGY (2017)
Boiling enriches the linear polysulfides and the hydrogen sulfide-releasing activity of garlic
Restituto Tocmo et al.
FOOD CHEMISTRY (2017)
被撤回的出版物: Diallyl trisulfide, a garlic polysulfide protects against As-induced renal oxidative nephrotoxicity, apoptosis and inflammation in rats by activating the Nrf2/ARE signaling pathway (Retracted article. See vol. 85, 2020)
S. Miltonprabu et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2017)
Garlic-derived organosulfur compound exerts antitumor efficacy via activation of MAPK pathway and modulation of cytokines in SGC-7901 tumor-bearing mice
Xiaoyan Jiang et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2017)
Suppressive role of diallyl trisulfide in the activated platelet-mediated hematogenous metastasis of MDA-MB-231 human breast cancer cells
Yuping Liu et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2017)
Allium vegetable intakes and the incidence of cardiovascular disease, hypertension, chronic kidney disease, and type 2 diabetes in adults: a longitudinal follow-up study
Zahra Bahadoran et al.
JOURNAL OF HYPERTENSION (2017)
Alliin, a garlic organosulfur compound, ameliorates gut inflammation through MAPK-NF-κB/AP-1/STAT-1 inactivation and PPAR-7 activation
Limin Shi et al.
MOLECULAR NUTRITION & FOOD RESEARCH (2017)
Fluorinated Analogs of Organosulfur Compounds from Garlic (Allium sativum): Synthesis, Chemistry and Anti-Angiogenesis and Antithrombotic Studies
Eric Block et al.
MOLECULES (2017)
The Cytotoxicity of the Ajoene Analogue BisPMB in WHCO1 Oesophageal Cancer Cells Is Mediated by CHOP/GADD153
Vuyolwethu Siyo et al.
MOLECULES (2017)
Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway
Siying Li et al.
ONCOLOGY REPORTS (2017)
Applications of Synthetic Organic Tetrasulfides as H2S Donors
Matthew M. Cerda et al.
ORGANIC LETTERS (2017)
Novel synthetic analogs of diallyl disulfide triggers cell cycle arrest and apoptosis &ITvia&IT ROS generation in MIA PaCa-2 cells
Vikas Saini et al.
PHARMACOLOGICAL REPORTS (2017)
Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1β-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-κB Pathway
Guang Yang et al.
BIOMED RESEARCH INTERNATIONAL (2017)
Cruciferous and Allium Vegetable Intakes are Inversely Associated With 15-Year Atherosclerotic Vascular Disease Deaths in Older Adult Women
Lauren C. Blekkenhorst et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2017)
New insights into the effects of onion consumption on lipid mediators using a diet-induced model of hypercholesterolemia
Diana Gonzalez-Pena et al.
REDOX BIOLOGY (2017)
Design, Synthesis and Anti-Cancer Activities of Benzyl Analogues of Garlic-Derived Diallyl Disulfide (DADS) and the Corresponding Diselenides
Debojit Bhattacherjee et al.
CHEMISTRYSELECT (2017)
Allicin Decreases Lipopolysaccharide-Induced Oxidative Stress and Inflammation in Human Umbilical Vein Endothelial Cells through Suppression of Mitochondrial Dysfunction and Activation of Nrf2
Min Zhang et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2017)
Synthesis and in vitro biological evaluation of thiosulfinate derivatives for the treatment of human multidrug-resistant breast cancer
Ariane Roseblade et al.
ACTA PHARMACOLOGICA SINICA (2017)
The Chemical Compositions of the Volatile Oils of Garlic (Allium sativum) and Wild Garlic (Allium vineale)
Prabodh Satyal et al.
FOODS (2017)
The garlic compound ajoene targets protein folding in the endoplasmic reticulum of cancer cells
Catherine H. Kaschula et al.
MOLECULAR CARCINOGENESIS (2016)
ROS-mediated activation of JNK/p38 contributes partially to the pro-apoptotic effect of ajoene on cells of lung adenocarcinoma
Yingyi Wang et al.
TUMOR BIOLOGY (2016)
Novel Angiogenic Activity and Molecular Mechanisms of ZYZ-803, a Slow-Releasing Hydrogen Sulfide-Nitric Oxide Hybrid Molecule
Qingxun Hu et al.
ANTIOXIDANTS & REDOX SIGNALING (2016)
The cytotoxicity of garlic-related disulphides and thiosulfonates in WHCO1 oesophageal cancer cells is dependent on S-thiolation and not production of ROS
Muneerah Smith et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2016)
Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry
Minghao Feng et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2016)
The synthetic ajoene analog SPA3015 induces apoptotic cell death through crosstalk between NF-κB and PPARγ in multidrug-resistant cancer cells
Jee Won Hwang et al.
FOOD AND CHEMICAL TOXICOLOGY (2016)
Inhibitory effects of S-allylmercaptocysteine against benzo(a) pyrene-induced precancerous carcinogenesis in human lung cells
Kaiming Wang et al.
INTERNATIONAL IMMUNOPHARMACOLOGY (2016)
Allicin Induces Thiol Stress in Bacteria through S-Allylmercapto Modification of Protein Cysteines
Alexandra Mueller et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2016)
DADS Analogues Ameliorated the Cognitive Impairments of Alzheimer-Like Rat Model Induced by Scopolamine
Apra Manral et al.
NEUROTOXICITY RESEARCH (2016)
Vasorelaxant Effect of a New Hydrogen Sulfide-Nitric Oxide Conjugated Donor in Isolated Rat Aortic Rings through cGMP Pathway
Dan Wu et al.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)
Gp130-mediated STAT3 activation by S-propargyl-cysteine, an endogenous hydrogen sulfide initiator, prevents doxorubicin-induced cardiotoxicity
J. Wu et al.
CELL DEATH & DISEASE (2016)
Protective Effect of Garlic on Cellular Senescence in UVB-Exposed HaCaT Human Keratinocytes
Hye Kyung Kim
NUTRIENTS (2016)
S-propargyl-cysteine attenuates inflammatory response in rheumatoid arthritis by modulating the Nrf2-ARE signaling pathway
Wei-Jun Wu et al.
REDOX BIOLOGY (2016)
S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6/STAT3 Pathway
Minjun Wang et al.
PLOS ONE (2016)
Multifunctional novel Diallyl disulfide (DADS) derivatives with β-amyloid-reducing, cholinergic, antioxidant and metal chelating properties for the treatment of Alzheimer's disease
Apra Manral et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Cardioprotective effects and pharmacokinetic properties of a controlled release formulation of a novel hydrogen sulfide donor in rats with acute myocardial infarction
Ba Hieu Tran et al.
BIOSCIENCE REPORTS (2015)
Garlic (A. sativum L.) alliinase gene family polymorphism reflects bolting types and cysteine sulphoxides content
Jaroslava Ovesna et al.
BMC GENETICS (2015)
Garlic and Onions: Their Cancer Prevention Properties
Holly L. Nicastro et al.
CANCER PREVENTION RESEARCH (2015)
The JNK Signaling Pathway Is a Novel Molecular Target for S-Propargyl-L-Cysteine, a Naturally-Occurring Garlic Derivatives: Link to Its Anticancer Activity in Pancreatic Cancer In Vitro and In Vivo
Wei Wang et al.
CURRENT CANCER DRUG TARGETS (2015)
Diallyl disulfide inhibits TNFα induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling
D. Bauer et al.
CYTOKINE (2015)
The protective effects of endogenous hydrogen sulfide modulator, S-propargyl-cysteine, on high glucose-induced apoptosis in cardiomyocytes: A novel mechanism mediated by the activation of Nrf2
Hebei Yang et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2015)
Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter
John L. Wallace et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
Diallyl Trisulfide Is a Fast H2S Donor, but Diallyl Disulfide Is a Slow One: The Reaction Pathways and Intermediates of Glutathione with Polysulfides
Dong Liang et al.
ORGANIC LETTERS (2015)
Garlic for hypertension: A systematic review and meta-analysis of randomized controlled trials
X. J. Xiong et al.
PHYTOMEDICINE (2015)
Diallyl trisulfide exerts anti-inflammatory effects in lipopolysaccharide-stimulated RAW 264.7 macrophages by suppressing the Toll-like receptor 4/nuclear factor-κB pathway
Hye Hyeon Lee et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2015)
Sulfoxides, Analogues of L-Methionine and L-Cysteine As Pro-Drugs against Gram-Positive and Gram-Negative Bacteria
N. V. Anufrieva et al.
ACTA NATURAE (2015)
S-Propargyl-Cysteine, a Novel Water-Soluble Modulator of Endogenous Hydrogen Sulfide, Promotes Angiogenesis Through Activation of Signal Transducer and Activator of Transcription 3
Juntao Kan et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
Composition of garlic essential oil (Allium sativum L.) as influenced by drying method
Salma Dziri et al.
JOURNAL OF ESSENTIAL OIL RESEARCH (2014)
SPRC protects hypoxia and re-oxygenation injury by improving rat cardiac contractile function and intracellular calcium handling
Yong-Hua Liang et al.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2014)
Diallyl Disulfide Suppresses SRC/Ras/ERK Signaling-Mediated Proliferation and Metastasis in Human Breast Cancer by Up-Regulating miR-34a
Xiangsheng Xiao et al.
PLOS ONE (2014)
Optimizing conditions for E-and Z-ajoene formation from garlic juice using response surface methodology
Miyoung Yoo et al.
FOOD SCIENCE & NUTRITION (2014)
Anti-Proliferative Activity of Synthetic Ajoene Analogues on Cancer Cell-Lines
Catherine H. Kaschula et al.
Anti-Cancer Agents in Medicinal Chemistry (2012)
Ajoene, a Sulfur-Rich Molecule from Garlic, Inhibits Genes Controlled by Quorum Sensing
Tim Holm Jakobsen et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells
Catherine H. Kaschula et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2012)
Novel diallyldisulfide analogs ameliorate cardiovascular remodeling in rats with L-NAME-induced hypertension
Dinesh Kumar Sharma et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2012)
Effects of S-Propargyl-Cysteine (SPRC) in Caerulein-Induced Acute Pancreatitis in Mice
Jenab N. Sidhapuriwala et al.
PLOS ONE (2012)
Dietary Administration of Scallion Extract Effectively Inhibits Colorectal Tumor Growth: Cellular and Molecular Mechanisms in Mice
Palanisamy Arulselvan et al.
PLOS ONE (2012)
S-propargyl-cysteine (ZYZ-802), a sulphur-containing amino acid, attenuates beta-amyloid-induced cognitive deficits and pro-inflammatory response: involvement of ERK1/2 and NF-κB pathway in rats
Qi-Hai Gong et al.
AMINO ACIDS (2011)
S-Propargyl-cysteine (SPRC) attenuated lipopolysaccharide-induced inflammatory response in H9c2 cells involved in a hydrogen sulfide-dependent mechanism
Li-Long Pan et al.
AMINO ACIDS (2011)
Ajoene, A Stable Garlic By-Product, Inhibits High Fat Diet-Induced Hepatic Steatosis and Oxidative Injury Through LKB1-Dependent AMPK Activation
Chang Yeob Han et al.
ANTIOXIDANTS & REDOX SIGNALING (2011)
S-Propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: Involvement of TNF signaling and NF-kappa B pathway in rats
Qi-Hai Gong et al.
BRAIN BEHAVIOR AND IMMUNITY (2011)
Reduction of Body Weight by Dietary Garlic Is Associated with an Increase in Uncoupling Protein mRNA Expression and Activation of AMP-Activated Protein Kinase in Diet-Induced Obese Mice
Mak-Soon Lee et al.
JOURNAL OF NUTRITION (2011)
H2S Donor, S-Propargyl-Cysteine, Increases CSE in SGC-7901 and Cancer-Induced Mice: Evidence for a Novel Anti-Cancer Effect of Endogenous H2S?
Kaium Ma et al.
PLOS ONE (2011)
Protective Effects of Cysteine Analogues on Acute Myocardial Ischemia: Novel Modulators of Endogenous H2S Production
Qian Wang et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
Garlic-derived anticancer agents: Structure and biological activity of ajoene
Catherine H. Kaschula et al.
BIOFACTORS (2010)
Synthesis and biological evaluation of novel leonurine-SPRC conjugate as cardioprotective agents
Chunhua Liu et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2010)
Ajoene, a Stable Garlic By-Product, Has an Antioxidant Effect through Nrf2-Mediated Glutamate-Cysteine Ligase Induction in HepG2 Cells and Primary Hepatocytes
Hee Yeon Kay et al.
JOURNAL OF NUTRITION (2010)
S-propargyl-cysteine Protects Both Adult Rat Hearts and Neonatal Cardiomyocytes From Ischemia/Hypoxia Injury: The Contribution of the Hydrogen Sulfide-Mediated Pathway
Qian Wang et al.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2009)
1,2-Vinyidithiin from Garlic Inhibits Differentiation and Inflammation of Human Preadipocytes
Mayoura Keophiphath et al.
JOURNAL OF NUTRITION (2009)
Inhibitory effect of novel diallyldisulfide analogs on HMG-CoA reductase expression in hypercholesterolemic rats: CREB as a potential upstream target
Santosh Kumar Rai et al.
LIFE SCIENCES (2009)
Synthesis, DNA binding, and cytotoxic evaluation of new analogs of diallyldisulfide, an active principle of garlic
Santosh Kumar Rai et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2008)
Substituted ajoenes as novel anti-cancer agents
Roger Hunter et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Hydrogen sulfide mediates the vasoactivity of garlic
Gloria A. Benavides et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Garlic-derived S-allylmercaptocysteine is a novel in vivo antimetastatic agent for androgen-independent prostate cancer
Edward W. Howard et al.
CLINICAL CANCER RESEARCH (2007)
A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms
Claus Jacob
NATURAL PRODUCT REPORTS (2006)
Composition, stability, and bioavailability of garlic products used in a clinical trial
LD Lawson et al.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2005)
Bioactive S-alk(en)yl cysteine sulfoxide metabolites in the genus Allium:: the chemistry of potential therapeutic agents
P Rose et al.
NATURAL PRODUCT REPORTS (2005)
Biosynthesis of the flavour precursors of onion and garlic
MG Jones et al.
JOURNAL OF EXPERIMENTAL BOTANY (2004)
Induction of detoxifying enzymes by garlic organosulfur compounds through transcription factor Nrf2: Effect of chemical structure and stress signals
C Chen et al.
FREE RADICAL BIOLOGY AND MEDICINE (2004)
Bis[3-(4'-substituted phenyl)prop-2-ene]disulfides as a new class of antihyperlipidemic compounds
M Sharma et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2004)
Comparative effects of mono-, di-, tri-, and tetrasulfides derived from plants of the allium family:: Redox cycling in vitro and hemolytic activity and phase 2 enzyme induction in vivo
R Munday et al.
FREE RADICAL BIOLOGY AND MEDICINE (2003)
Diallyl disulfide (DADS) induces the antitumorigenic NSAID-activated gene (NAG-1) by a p53-dependent mechanism in human colorectal HCT 116 cells
FG Bottone et al.
JOURNAL OF NUTRITION (2002)
Oxidation chemistry of perfluoroalkyl-segmented thiols, disulfides, thiosulfinates and thiosulfonates - The role of the perfluoroalkyl group in searching out new chemistry
NO Brace
JOURNAL OF FLUORINE CHEMISTRY (2000)