期刊
MOLECULES
卷 24, 期 20, 页码 -出版社
MDPI
DOI: 10.3390/molecules24203778
关键词
saturated oxygen heterocycles; cyclic ethers; total synthesis
资金
- National Research Foundation of Korea's (NRF) - Korea government (MSIT) [NRF 2018R1A5A2023127]
Saturated oxygen heterocycles are widely found in a broad array of natural products and other biologically active molecules. In medicinal chemistry, small and medium rings are also important synthetic intermediates since they can undergo ring-opening and -expansion reactions. These applications have driven numerous studies on the synthesis of oxygen-containing heterocycles and considerable effort has been devoted toward the development of methods for the construction of saturated oxygen heterocycles. This paper provides an overview of the biological roles and synthetic strategies of saturated cyclic ethers, covering some of the most studied and newly discovered related natural products in recent years. This paper also reports several promising and newly developed synthetic methods, emphasizing 3-7 membered rings.
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