期刊
MOLECULAR PHARMACEUTICS
卷 16, 期 12, 页码 4757-4774出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.molpharmaceut.9b00945
关键词
polymeric micelles; pluronic/poloxamers; tetronic/poloxamines; cancer; theranostic
资金
- Portuguese National Funds (FCT/MEC, Fundack para a Ciencia e Tecnologia/Ministerio da Educacio e Cfencia) [UID/QUI/50006/2013]
- European Union (FEDER under the Partnership Agreement PT2020)
- Portuguese Foundation for Science and Technology (FCT) [POCI-01-0145-FEDER-030255 (PTDC/BTM-MAT/30255/2017)]
- European Community Fund (FEDER) through the COMPETE2020 program
- MINECO [SAF2017-8311812]
- Agencia Estatal de Investigation (AEI) Spain
- Xunta de Galicia [ED431C 2016/008, ED431E 2018/08]
- FEDER (Spain)
Cancer is a leading cause of death worldwide. Despite the advances in prevention, detection, diagnosis, and treatment, many tumors relapse and become resistant to conventional treatments. Theranostics and real-time molecular imaging using nanoscale materials, such as polymeric micelles, are being widely explored as promising gold standard approaches in a personalized medicine perspective for cancer. Theranostics is intended for the three-in-one purpose of simultaneously diagnose, treat, and monitor tumor evolution. Compared to the conventional treatments, theranostic functional polymeric micelles have demonstrated great potential to improve and monitor the delivery of pharmacological agents following administration, which can enhance therapeutic efficacy and minimize off-target toxicity. This review provides an overview of the current state of the art related to the use of polymeric micelles as theranostic multicarriers targeting the cancer cells and tumor microenvironment. Some future directions toward the design of nanotheranostic platforms are also proposed. In particular, we focused our attention on Pluronics and Tetronics as they advantageously present sol-gel transition, which makes them smart nanosystems suitable for oral theranostic administration and sustained depots, increasing patient compliance.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据