期刊
MOLECULAR DIVERSITY
卷 24, 期 4, 页码 1343-1353出版社
SPRINGER
DOI: 10.1007/s11030-019-09998-5
关键词
Deoxy-isoequilenine; Betti-condensation; Chiral ligands; Absolute configuration; Diethylzinc addition
类别
资金
- National Science Fund, Bulgaria [UNA 17/2005, DRNF 02/13/2009, DRNF-02/1/2009]
The utility of deoxy-isoequilenine synthesized from estrone as valuable 2-naphthol analogue is demonstrated in the three components Betti-condensation. A simple, efficient and green procedure for the synthesis of aminobenzylnaphthol analogues (so-called Betti bases) has been realized highly diastereoselectively by using (S)-phenylethylamine and 1- or 2-naphthaldehyde. The absolute configuration of the new chiral compounds obtained has been determined by means of NMR experiments and confirmed by X-ray crystallography. The chiral steroidal aminobenzylnaphthols have been evaluated as pre-catalysts for the addition of diethylzinc to aldehydes with enantioselectivities of up to 98% ee.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据