期刊
MOLECULAR BIOLOGY AND EVOLUTION
卷 37, 期 4, 页码 943-951出版社
OXFORD UNIV PRESS
DOI: 10.1093/molbev/msz280
关键词
population structure; population genetics; human genetics; isolation-by-distance; geography; geographic structure
资金
- NIH/NCI [U01 CA198933]
- NIH/NIGMS [R01 GM108805, R01 GM132383]
- Swiss National Science Foundation
- University of Chicago Research Computing Center
Geographic patterns in human genetic diversity carry footprints of population history and provide insights for genetic medicine and its application across human populations. Summarizing and visually representing these patterns of diversity has been a persistent goal for human geneticists, and has revealed that genetic differentiation is frequently correlated with geographic distance. However, most analytical methods to represent population structure do not incorporate geography directly, and it must be considered post hoc alongside a visual summary of the genetic structure. Here, we estimate effective migration surfaces to visualize how human genetic diversity is geographically structured. The results reveal local patterns of differentiation in detail and emphasize that while genetic similarity generally decays with geographic distance, the relationship is often subtly distorted. Overall, the visualizations provide a new perspective on genetics and geography in humans and insight to the geographic distribution of human genetic variation.
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