期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 20, 期 5, 页码 396-407出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557519666191015202723
关键词
Embelin; anticancer; anti-inflammatory activity; benzoquinone; XIAP antagonist; natural product
资金
- Natural Science Foundation of Guangdong Province [2016A030310441]
- Science Foundation for Young Teachers of Wuyi University [2016td01]
- Jiangmen Project for Innovative Research Team [2018630100180019806]
- Department of Education of Guangdong Province [2016KCXTD005, 2017KSYS010]
Embelin is a naturally occurring para-benzoquinone isolated from Embelia ribes (Burm. f.) of the Myrsinaceae family, and contains two carbonyl groups, a methine group and two hydroxyl groups. With embelin as the lead compound, more than one hundred derivatives have been reported. Embelin is well known for its ability to antagonize the X-linked inhibitor of apoptosis protein (XIAP) with an IC50 value of 4.1 mu M. The potential of embelin and its derivatives in the treatment of various cancers has been extensively studied. In addition, these compounds display a variety of other biological effects: antimicrobial, antioxidant, analgesic, anti-inflammatory, anxiolytic and antifertility activity. This paper reviews the recent progress in the synthesis and biological activity of embelin and its derivatives. Their cellular mechanisms of action and prospects in the research and development of new drugs arc also discussed.
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