期刊
MINI-REVIEWS IN MEDICINAL CHEMISTRY
卷 20, 期 5, 页码 342-368出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389557519666191014142448
关键词
Hydrazones; guanylhydrazones; biologic activity; medicinal chemistry; Alzheimer's; cancer; leishmaniasis
资金
- Brazilian agency: National Council for Scientific and Technological Development (CNPq) [306156/2015-6]
- Brazilian agency: Brazilian Federal Agency for Support and Evaluation of Graduate Education (CAPES)
- Brazilian agency: National Institute of Science and Technology of Structural Biology and bioimages (INBEB)
- Brazilian agency: Rio de Janeiro Research Foundation (FAPERJ) [02/202.961/2017]
- Long-term development plan UHK
Hydrazones and their derivatives are very important compounds in medicinal chemistry due to their reported biological activity for the treatment of several diseases, like Alzheimer's, cancer, inflammation, and leishmaniasis. However, most of the investigations on hydrazones available in literature today are directed to the synthesis of these molecules with little discussion available on their biological activities. With the purpose of bringing lights into this issue, we performed a revision of the literature and wrote this review based on some of the most current research reports of hydrazones and derivatives, making it clear that the synthesis of these molecules can lead to new drug prototypes. Our goal is to encourage more studies focused on the synthesis and evaluation of new hydrazones, as a contribution to the development of potential new drugs for the treatment of various diseases.
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