期刊
MICROCHIMICA ACTA
卷 186, 期 12, 页码 -出版社
SPRINGER WIEN
DOI: 10.1007/s00604-019-3916-5
关键词
Metal-organic frameworks (MOFs); MagG@PDA@Ni-MOF@Fe-MOF; Immobilized metal ion affinity chromatography (IMAC); MALDI-TOF mass spectrometry; Phosphopeptides
资金
- Zhejiang Natural Science Foundation [LQ19C050002]
- Ningbo Natural Science Foundation [2018A610279]
- K. C. Wong Magna Fund in Ningbo University
A binary magnetic metal-organic framework (MOF)-functionalized material (magG@PDA@Ni-MOF@Fe-MOF) was prepared through grafting Ni-MOF and Fe-MOF on magnetic (Fe3O4) graphene with polydopamine (PDA) as a middle layer. Compared with single MOFs functionalized materials (magG@PDA@Ni-MOF and magG@PDA@Fe-MOF) under the same conditions, magG@PDA@Ni-MOF@Fe-MOF not only displays lower detection limits (4 fmol) and selectivity (1:1000), but also has better enrichment efficiency for both multi-and monophosphopeptides. Other than this, magG@PDA@Ni-MOF@Fe-MOF exhibits fine reusability (five cycles) and rapid enrichment property (1 min), and 24 phosphopeptides were detected when it was applied to the analysis of human saliva.
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