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FREE RADICAL BIOLOGY AND MEDICINE (2008)
UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide
Diona L. Damian et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2008)
Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau
Kim N. Green et al.
JOURNAL OF NEUROSCIENCE (2008)
IRF-1 is required for full NF-kappa B transcriptional activity at the human immunodeficiency virus type 1 long terminal repeat enhancer
Marco Sgarbanti et al.
JOURNAL OF VIROLOGY (2008)
Attenuation of sarcopenia by dietary restriction in rhesus monkeys
Ricki J. Colman et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2008)
SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70
Nagalingam R. Sundaresan et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease
Heng Du et al.
NATURE MEDICINE (2008)
Paths of convergence: Sirtuins in aging and neurodegeneration
Li Gan et al.
NEURON (2008)
SIRT1 Overexpression Antagonizes Cellular Senescence with Activated ERK/S6k1 Signaling in Human Diploid Fibroblasts
Jing Huang et al.
PLOS ONE (2008)
A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy
In Hye Lee et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
Bong-Hyun Ahn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
miR-34a repression of SIRT1 regulates apoptosis
Munekazu Yamakuchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Mechanisms of macrophage activation in obesity-induced insulin resistance
Justin I. Odegaard et al.
NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM (2008)
Nicotinamide uncouples hormone-dependent chromatin remodeling from transcription complex assembly
Sayura Aoyagi et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Nampt/PBEF/Visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme
Javier R. Revollo et al.
CELL METABOLISM (2007)
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival
Hongying Yang et al.
CELL (2007)
1-methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway
S. Chlopicki et al.
BRITISH JOURNAL OF PHARMACOLOGY (2007)
Prediction and prevention of type 1 diabetes: Progress, problems, and prospects
J. S. Skyler
CLINICAL PHARMACOLOGY & THERAPEUTICS (2007)
Nicotinamide inhibits B lymphocyte activation by disrupting MAPK signal transduction
Julien Daniel et al.
BIOCHEMICAL PHARMACOLOGY (2007)
SIRT1 promotes DNA repair activity and deacetylation of Ku70
Jaemin Jeong et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2007)
NAD+ metabolism in health and disease
Peter Belenky et al.
TRENDS IN BIOCHEMICAL SCIENCES (2007)
Translational mini-review series on type 1 diabetes: Immune-based therapeutic approaches for type 1 diabetes
T. Staeva-Vieira et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2007)
Hormonal control of androgen receptor function through SIRT1
Maofu Fu et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Nicotinamide extends replicative lifespan of human cells
Hyun Tae Kang et al.
AGING CELL (2006)
Zinc neurotoxicity is dependent on intracellular NAD+ levels and the sirtuin pathway
Ai-Li Cai et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Nampt/PBEF/Visfatin: A regulator of mammalian health and longevity?
Hongying Yang et al.
EXPERIMENTAL GERONTOLOGY (2006)
SIRT1 and endocrine signaling
Tianle Yang et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2006)
Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
CM Bäckesjö et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2006)
Acetylation of estrogen receptor α by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor
Mi Young Kim et al.
MOLECULAR ENDOCRINOLOGY (2006)
Selective potentiation of Stat-dependent gene expression by collaborator of Stat6 (CoaSt6), a transcriptional cofactor
S Goenka et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Nicotinamide protected first-phase insulin response (FPIR) and prevented clinical disease in first-degree relatives of type-1 diabetics
PR Olmos et al.
DIABETES RESEARCH AND CLINICAL PRACTICE (2006)
Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic β cells
L Bordone et al.
PLOS BIOLOGY (2006)
Cell life versus cell longevity: The mysteries surrounding the NAD(+) precursor nicotinamide
FQ Li et al.
CURRENT MEDICINAL CHEMISTRY (2006)
SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-κB signaling
J Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing
Z Benyó et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Nicotinamide induces apoptosis and reduces collagen I and pro-inflammatory cytokines expression in rat hepatic stellate cells
A Traister et al.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2005)
The sirtuin inhibitor nicotinamide enhances neuronal cell survival, during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated anti-apoptotic pathways
ZZ Chong et al.
CURRENT NEUROVASCULAR RESEARCH (2005)
Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice
KA Moynihan et al.
CELL METABOLISM (2005)
Nicotinamide prevents the development of hyperphosphataemia by suppressing intestinal sodium-dependent phosphate transporter in rats with adenine-induced renal failure
N Eto et al.
NEPHROLOGY DIALYSIS TRANSPLANTATION (2005)
Nuclear poly(ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction
G Cipriani et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mechanism of sirtuin inhibition by nicotinamide:: Altering the NAD+ cosubstrate specificity of a Sir2 enzyme
JL Avalos et al.
MOLECULAR CELL (2005)
Moisturizing effects of topical nicotinamide on atopic dry skin
Y Soma et al.
INTERNATIONAL JOURNAL OF DERMATOLOGY (2005)
The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): systematic review of the literature
Jonathan Prousky et al.
NUTRITION JOURNAL (2005)
Autotoxicity, methylation and a road to the prevention of Parkinson's disease
AC Williams et al.
JOURNAL OF CLINICAL NEUROSCIENCE (2005)
Poly(ADP-ribosyl)ation by PARP-1: 'PAR-laying' NAD(+) into a nuclear signal
MY Kim et al.
GENES & DEVELOPMENT (2005)
A randomized trial of nicotinamide and vitamin E in children with recent onset type 1 diabetes (IMDIAB IX)
A Crinò et al.
EUROPEAN JOURNAL OF ENDOCRINOLOGY (2004)
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans
L Fontana et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
A Brunet et al.
SCIENCE (2004)
European Nicotinamide Diabetes Intervention Trial (ENDIT):: a randomised controlled trial of intervention before the onset of type 1 diabetes
EAM Gale et al.
LANCET (2004)
Nicotinamide suppresses hyperphosphatemia in hemodialysis patients
Y Takahashi et al.
KIDNEY INTERNATIONAL (2004)
NAD+-dependent modulation of chromatin structure and transcription by nucleosome binding properties of PARP-1
MY Kim et al.
CELL (2004)
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
HY Cohen et al.
SCIENCE (2004)
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2SIRT1
A van der Horst et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The NAD+ precursor nicotinamide governs neuronal survival during oxidative stress through protein kinase B coupled to FOXO3a and mitochondrial membrane potential
ZZ Chong et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2004)
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
F Picard et al.
NATURE (2004)
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
F Yeung et al.
EMBO JOURNAL (2004)
Sirtuins: Sir2-related NAD-dependent protein deacetylases
BJ North et al.
GENOME BIOLOGY (2004)
Tryptophan depletion and HIV infection: a metabolic link to pathogenesis
MF Murray
LANCET INFECTIOUS DISEASES (2003)
Nitric oxide:: NO apoptosis or turning it ON?
B Brüne
CELL DEATH AND DIFFERENTIATION (2003)
Nicotinamide: a potential addition to the anti-psoriatic weaponry
MR Namazi
FASEB JOURNAL (2003)
Niacin for dyslipidemia: Considerations in product selection
J McKenney
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2003)
High expression of nicotinamide N-methyltransferase in patients with idiopathic Parkinson's disease
RB Parsons et al.
NEUROSCIENCE LETTERS (2003)
HIF-1α is essential for myeloid cell-mediated inflammation
T Cramer et al.
CELL (2003)
Nicotinamide offers multiple protective mechanisms in stroke as a precursor for NAD(+), as a PARP inhibitor and by partial restoration of mitochondrial function
L Klaidman et al.
PHARMACOLOGY (2003)
ARCON: a novel biology-based approach in radiotherapy
JHAM Kaanders et al.
LANCET ONCOLOGY (2002)
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast Sir2 and human SIRT1
KJ Bitterman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The effects of nicotinamide on energy metabolism following transient focal cerebral ischemia in Wistar rats
J Yang et al.
NEUROSCIENCE LETTERS (2002)
The therapeutic potential of poly(ADP-ribose) polymerase inhibitors
L Virág et al.
PHARMACOLOGICAL REVIEWS (2002)
N-methylation underlying Parkinson's disease
K Matsubara et al.
NEUROTOXICOLOGY AND TERATOLOGY (2002)
The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer
T Hakozaki et al.
BRITISH JOURNAL OF DERMATOLOGY (2002)
Activation of poly(ADP-ribose) polymerase-1 is a central mechanism of lipopolysaccharide-induced acute lung inflammation
L Liaudet et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2002)
Conversion of L-tryptophan to serotonin and melatonin in human melanoma cells
A Slominski et al.
FEBS LETTERS (2002)
C/EBP alpha induces adipogenesis through PPAR gamma: a unified pathway
ED Rosen et al.
GENES & DEVELOPMENT (2002)
Nicotinamide protects HCN2 cells from the free radical generating toxin, tertiary-butylhydroperoxide (t-BuOOH)
Manisha Sonee et al.
NEUROTOXICITY RESEARCH (2002)
Nicotinamide modulates mitochondrial membrane potential and cysteine protease activity during cerebral vascular endothelial cell injury
ZZ Chong et al.
JOURNAL OF VASCULAR RESEARCH (2002)
Impact of tumor hypoxia and anemia on radiation therapy outcomes
LB Harrison et al.
ONCOLOGIST (2002)
The enzymatic and DNA binding activity of PARP-1 are not required for NF-κB coactivator function
PO Hassa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
NAD(P)H, a directly operating antioxidant?
M Kirsch et al.
FASEB JOURNAL (2001)
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes
CY Zhang et al.
CELL (2001)
Poly(ADP-ribose) polymerase-1 is required for efficient HIV-1 integration
HC Ha et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Poly(ADP-ribose) binds to specific domains in DNA damage checkpoint proteins
JM Pleschke et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Safety of high dose nicotinamide: a review
M Knip et al.
DIABETOLOGIA (2000)
Delayed treatment with nicotinamide (vitamin B3) improves neurological outcome and reduces infarct volume after transient focal cerebral ischemia in Wistar rats
T Mokudai et al.
STROKE (2000)
Proliferation kinetics and differentiation potential of ex vivo expanded human bone marrow stromal cells: Implications for their use in cell therapy
A Banfi et al.
EXPERIMENTAL HEMATOLOGY (2000)
Zinc-induced cortical neuronal death:: Contribution of energy failure attributable to loss of NAD+ and inhibition of glycolysis
CT Sheline et al.
JOURNAL OF NEUROSCIENCE (2000)
High-dose pyridoxine as an 'anti-stress' strategy
MF McCarty
MEDICAL HYPOTHESES (2000)
Prevention of nitric oxide-induced neuronal injury through the modulation of independent pathways of programmed cell death
SH Lin et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2000)
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