期刊
MENDELEEV COMMUNICATIONS
卷 29, 期 6, 页码 613-615出版社
ELSEVIER
DOI: 10.1016/j.mencom.2019.11.002
关键词
-
资金
- Russian Science Foundation [17-73-10136]
- Russian Foundation for Basic Research [17-43-020502]
- Russian Science Foundation [17-73-10136] Funding Source: Russian Science Foundation
New macrodiolides incorporating 1Z,5Z-diene and 1,3-diyne moieties were obtained in 55-79% yields and with >98% stereoselectivity by Hf(OTf)(4)-catalyzed intermolecular cyclo-condesation of (5Z,9Z)-tetradeca-5,9-diene-1,14-dioic acid with alpha,omega-diols. Alternative route included intramolecular oxidative coupling of alpha,omega-diynes, esterification products of (5Z,9Z)-tetradeca-5,9-diene-1,14-dioic acid with alkynols. The macrodiolides synthesized exhibit in vitro cytotoxic activity toward Jurkat, K562, U937, HL-60, HeLa and Hek293 cell lines.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据