期刊
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
卷 209, 期 3, 页码 277-299出版社
SPRINGER
DOI: 10.1007/s00430-019-00644-3
关键词
Gram-negative bacteria; Adhesins; Extracellular matrix proteins; Fibronectin; Collagen; Laminin
资金
- Viral and Bacterial Adhesin Network Training (ViBrANT) Program - European Union's HORIZON 2020 Research and Innovation Program under the Marie Sklodowska-Curie Grant [765042]
- Deutsche Forschungsgemeinschaft [DFG FOR 2251]
- Robert Koch-Institute, Berlin, Germany (Bartonella consiliary laboratory) [1369-354]
The capacity of pathogenic microorganisms to adhere to host cells and avoid clearance by the host immune system is the initial and most decisive step leading to infections. Bacteria have developed different strategies to attach to diverse host surface structures. One important strategy is the adhesion to extracellular matrix (ECM) proteins (e.g., collagen, fibronectin, laminin) that are highly abundant in connective tissue and basement membranes. Gram-negative bacteria express variable outer membrane proteins (adhesins) to attach to the host and to initiate the process of infection. Understanding the underlying molecular mechanisms of bacterial adhesion is a prerequisite for targeting this interaction by anti-ligands to prevent colonization or infection of the host. Future development of such anti-ligands (specifically interfering with bacteria-host matrix interactions) might result in the development of a new class of anti-infective drugs for the therapy of infections caused by multidrug-resistant Gram-negative bacteria. This review summarizes our current knowledge about the manifold interactions of adhesins expressed by Gram-negative bacteria with ECM proteins and the use of this information for the generation of novel therapeutic antivirulence strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据