期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2019.109972
关键词
Dual-modal imaging nanoprobe; Photoluminescence imaging; Magnetic resonance imaging; Iridium(III) complexes; Gd(Si-DTTA)
资金
- Natural Science Foundation of China [21171038]
- Fujian Province [2016J01054]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_15R11]
- Shenzhen Basic Research Program [JCYJ20170307140752183]
- Guangdong Natural Science Foundation [2017A030313076]
The combination of non-invasive fluorescence (FL) and magnetic resonance (MR) imaging can compensate for disadvantages in terms of resolution and sensitivity. However, the preparation of dual-mode probes simultaneously exhibiting strong brightness and high MR response is challenging. A multifunctional nanoprobe was synthesized for targeted photoluminescence (PL) and MR dual-modal imaging. It was obtained by conjugating iridium(III) complexes, gadolinium(III) and the peptide arginine-glycine-aspartate (RGD) onto silica nanoparticles (Ir@SiO2-Gd-RGD NPs). They are highly water soluble, have an average diameter of similar to 50 nm, and emit strong yellowish green PL (with excitation/emission peaks at 380/572 nm). Simultaneously, the nanoprobes exhibit high MR response with a longitudinal relaxation of 7.16 mM(-1) s(-1). Instead of simple encapsulation, Ir (III) complexes were covalently conjugated to silica matrix to enhance the chemical and photochemical stability of the nanoprobes. The excellent biocompatibility and PL/MR dual modal imaging capability of the NPs is demonstrated using HeLa cells and mice as models.
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