期刊
出版社
ELSEVIER
DOI: 10.1016/j.msec.2019.109865
关键词
Iridium oxide; Neural stem cell; Biocompatibility; Electrical stimulation; Neurite alignment; Neurite extension
资金
- National Natural Science Foundation of China [51502265]
- Natural Science Foundation of Zhejiang Province [LQ16E020006]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Republic of Korea [2015R1D1A1A09058875]
- Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences
- National Research Foundation of Korea [2015R1D1A1A09058875] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Iridium (Ir) thin film was deposited on patterned titanium substrate by direct-current (DC) magnetron sputtering, and then activated in sulfuric acid (H2SO4) through repetitive potential sweeps to form iridium oxide (IrOx) as neural electrode interface. The resultant IrOx film showed a porous and open morphology with aligned microstructure, exhibited superior electrochemical performance and excellent stability. The IrOx film supported neural stem cells (NSCs) attachment, proliferation and improved processes without causing toxicity. The patterned IrOx films offered a unique system to investigate the synergistic effects of topographical cue and electrical stimulation on neurite outgrowth. Electrical stimulation, when applied through patterned IrOx films, was found to further increase the neurite extension of neuron-like cells and significantly reorient the neurite alignment towards to the direction of stimulation. These results indicate that IrOx film, as electrode-tissue interface is highly stable and biocompatible with excellent electrochemical properties.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据