期刊
MARINE DRUGS
卷 17, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/md17110618
关键词
Smenospongia aurea; marine natural products; structure elucidation; anti-tumor lead molecules; smenamides; solid tumor cell lines; conformational analysis
资金
- Ministero dell'Istruzione, dell'Universita e della Ricerca (PRIN) [2015MSCKCE_003]
- Regione Campania, PO FESR 2014-2020, O.S. 1.2, Project Campania Oncoterapie [B61G18000470007]
Caribbean sponges of the genus Smenospongia are a prolific source of chlorinated secondary metabolites. The use of molecular networking as a powerful dereplication tool revealed in the metabolome of S. aurea two new members of the smenamide family, namely smenamide F (1) and G (2). The structure of smenamide F (1) and G (2) was determined by spectroscopic analysis (NMR, MS, ECD). The relative and the absolute configuration at C-13, C-15, and C-16 was determined on the basis of the conformational rigidity of a 1,3-disubstituted alkyl chain system (i.e., the C-12/C-18 segment of compound (1). Smenamide F (1) and G (2) were shown to exert a selective moderate antiproliferative activity against cancer cell lines MCF-7 and MDA-MB-231, while being inactive against MG-63.
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