期刊
MARINE DRUGS
卷 17, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/md17100579
关键词
marine-derived fungi; secondary metabolites; polyketides; drimanes; meroterpenoids; cytotoxicity
资金
- Russian Science Foundation [19-74-10014]
- Russian Foundation of Basic Research [18-34-00737, 19-53-54002]
- Vietnam Academy of Science and Technology [QTRU01.03/19-20]
- Russian Science Foundation [19-74-10014] Funding Source: Russian Science Foundation
Four new compounds were isolated from the Vietnamese marine sediment-derived fungus Aspergillus flocculosus, one aspyrone-related polyketide aspilactonol G (2), one meroterpenoid 12-epi-aspertetranone D (4), two drimane derivatives (7,9), together with five known metabolites (1,3,5,6,8,10). The structures of compounds 1-10 were established by NMR and MS techniques. The absolute stereoconfigurations of compounds 1 and 2 were determined by a modified Mosher's method. The absolute configurations of compounds 4 and 7 were established by a combination of analysis of ROESY data and coupling constants as well as biogenetic considerations. Compounds 7 and 8 exhibited cytotoxic activity toward human prostate cancer 22Rv1, human breast cancer MCF-7, and murine neuroblastoma Neuro-2a cells.
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