期刊
MAGNETIC RESONANCE IMAGING
卷 63, 期 -, 页码 235-243出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.mri.2019.08.031
关键词
Myelin; Proton density; Quantitative magnetic resonance imaging; Relaxation time; Relaxometry; Synthetic magnetic resonance imaging
资金
- JSPS KAKENHI [19K17177, 19K17150, 18K07692, 16K10327, JP16H06280]
- Ministry of Economy, Industry, and Trade (METI)
- Japan Agency for Medical Research and Development (AMED) [181k1010025s0101, 191k1010025h9902]
- Brain/MINDS Beyond program from AMED [JP19dm0307024h002]
- Japanese Society for Magnetic Resonance in Medicine
- Grants-in-Aid for Scientific Research [16K10327, 18K07692] Funding Source: KAKEN
Background: Previous methods for the quantification of brain tissue properties by magnetic resonance imaging were mainly based on two-dimensional acquisitions and were thus limited to a relatively low resolution in the slice direction compared to three-dimensional (3D) acquisitions. The 3D-quantification using an interleaved Look-Locker acquisition sequence with a T2 preparation pulse (3D-QALAS) sequence may allow for simultaneous acquisition of relaxometry parameters in high spatial resolution. Purpose: To evaluate bias, linearity, and day-to-day repeatability of relaxometry parameters, as well as tissue fraction maps, acquired with 3D-QALAS. Materials and methods: Scan-rescan test of the 3D-QALAS sequence was performed on a 1.5-T scanner with the International Society for Magnetic Resonance in Medicine/National institute of Standards and Technology system phantom and 10 healthy volunteers (7 male, 3 female; mean age, 23.2 +/- 3.6 years). Simple linear regression analysis, Bland-Altman plots, and intrasubject coefficients of variation (CV) were used to assess the reliability of 3D-QALAS sequence-derived parameters. The T1, T2, proton density (PD), and myelin volume fraction (MVF) of in vivo brain regions were compared with values obtained using the multidynamic multi-echo sequence. Results: In the phantom study, the T1, T2, and PD values measured by 3D-QALAS showed strong linearity with the reference values (R-2 = 0.998, 0.998, and 0.960 for T1, T2, and PD, respectively) and high repeatability (mean CV of 1.2%, 2.8%, and 2.9% for T1, T2, and PD, respectively). The T1, T2, PD, and MVF values of in vivo brain regions obtained with 3D-QALAS were highly consistent within subjects, with mean intrasubject CVs of 0.5%, 0.5%, 0.4%, and 1.6% for the T1, T2, PD, and MVF values, respectively. Conclusion: 3D-QALAS enables reliable measurement of T1, T2, PD, and MVF values of the whole brain in high spatial resolution across a clinically-relevant dynamic range.
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