期刊
MACROMOLECULES
卷 52, 期 20, 页码 7668-7677出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.macromol.9b01252
关键词
-
资金
- Natural Science Foundation of China (NNSFC) project [51722307, 51673179]
- Fundamental Research Funds for the Central Universities [WK3450000003]
Bacterial infection poses a massive threat to our society, and bacterial biofilm is a major cause of chronic and recurrent infections. The treatment of bacterial biofilms represents a challenging task, and the development of antibacterial materials that can not only disperse bacterial biofilms but also kill bacteria is of increasing interest. Herein, we report the fabrication of well-defined nitric oxide (NO)-releasing amphiphiles, poly(ethylene oxide)-b-polyCouNO (PEO-b-PCouNO), where CouNO is an N-nitrosoamine-based NO donor containing a coumarin chromophore, exhibiting visible-light-mediated and self-reporting NO-release behavior. Unlike conventional polymeric NO donors derived from N-diazeniumdiolate (NONOates) or N-nitrosothiol (SNOs) that could be only synthesized via the postmodification procedure due to poor stability, the newly developed Nnitrosoamine-based NO donors can be directly polymerized into amphiphiles using reversible addition-fragmentation chain transfer (RAFT) polymerization. The NO-releasing amphiphiles self-assembled into micelles and selective NO release in aqueous medium was achieved by irradiating the micelle solution with visible light, which was characterized by a remarkable fluorescence turn-on (>185-fold), thereby enabling in situ self-reporting NO release. The photoinduced NO release can efficiently disperse bacterial biofilm of Pseudomonas aeruginosa. Moreover, antibiotics (e.g., Ciprofloxacin, Cip) could be loaded into the NO-releasing micelles, and co-delivery of NO and Cip was achieved, allowing for simultaneous biofilm dispersal and bacterial killing. This work provides a new strategy to fabricate macromolecular NO donors, which can efficiently avoid uncontrolled NO leakage and display promising antibacterial applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据