期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 49, 页码 19263-19268出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b11298
关键词
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资金
- JSPS Kakenhi [JP17H06450, JP26220803, JP18H01975]
- Japan Society for the Promotion of Science (JSPS)
Optically active sulfoximines are a promising substance in medicinal chemistry. However, a methodology for preparing chiral sulfoximines in a stereoselective manner has been underdeveloped. Here, we report an asymmetric synthesis of chiral sulfoximines having an aryl group by the newly developed sulfur-selective arylation of easily accessible chiral sulfinamides. The utility of the present method is demonstrated by the asymmetric synthesis of a key intermediate of a COX-2 inhibitor.
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