期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 50, 页码 19823-19830出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b09899
关键词
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资金
- Rutgers Global Collaborative Research Grant
- Busch Biomedical Award
- Australian Research Council [DE170100315]
- Australian Research Council [DE170100315] Funding Source: Australian Research Council
Structure-function relationships for multivalent polymer scaffolds are highly complex due to the wide diversity of architectures offered by such macromolecules. Evaluation of this landscape has traditionally been accomplished case-by-case due to the experimental difficulty associated with making these complex conjugates. Here, we introduce a simple dual-wavelength, two-step polymerize and click approach for making combinatorial conjugate libraries. It proceeds by incorporation of a polymerization friendly cyclopropenone-masked dibenzocyclooctyne into the side chain of linear polymers or the a-chain end of star polymers. Polymerizations are performed under visible light using an oxygen tolerant porphyrin-catalyzed photoinduced electron/energy transfer-reversible addition-fragmentation chain-transfer (PET-RAFT) process, after which the deprotection and click reaction is triggered by UV light. Using this approach, we are able to precisely control the valency and position of ligands on a polymer scaffold in a manner conducive to high throughput synthesis.
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