期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 45, 页码 17973-17977出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b09181
关键词
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资金
- National Basic Research Program of China [2015CB856300]
- National Natural Science Foundation of China [21571099, 21977044, 21731004]
Tracking signaling H2S in live mice demands responsive imaging with fine tissue imaging depth and low interferences from tissue scattering/autofluorescence and probe concentration. With complementary advantages of fluorescence and photoacoustic (PA) imaging, optical/PA dual-modality imaging was suggested for in/ex vivo H2S imaging. Therefore, a meso-benzoyloxyltricarboheptamethine cyanine, HS-CyBz, was prepared as the first ratiometric optical/PA dual-modality probe for H2S, profiting from a keto-enol transition sensing mechanism. Tail intravenous injection of this probe leads to probe accumulation in the liver of mice, and the endogenous H2S upregulation triggered by S-adenosyl-l-methionine has been verified by ratiometric optical/PA imaging, suggesting the promising potential of this ratiometric dual-modality imaging.
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