期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 42, 页码 16590-16594出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b08746
关键词
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资金
- NIH [R01 GM120530]
- Bristol-Myers Squibb
We report here a photocatalytic method for the intermolecular anti-Markovnikov hydroamination of unactivated olefins with primary alkyl amines to selectively furnish secondary amine products. These reactions proceed through aminium radical cation (ARC) intermediates and occur at room temperature under visible light irradiation in the presence of an iridium photocatalyst and an aryl thiol hydrogen atom donor. Despite the presence of excess olefin, high selectivities are observed for secondary over tertiary amine products, even though the secondary amines are established substrates for ARC-based olefin amination under similar conditions.
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