期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 84, 期 21, 页码 13252-13261出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.9b00821
关键词
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资金
- Natural Sciences and Engineering Research Council of Canada
- University of Western Ontario
A selection of benzyl-based protecting groups for thiouracil (U-s) for the synthesis of pseudo-complementary peptide nucleic acid (PNA) has been evaluated. The 4-methoxybenzyl-protecting group that has found use for s U during Boc-based oligomerization is also suitable for Fmoc-based oligomerization. Furthermore, it is demonstrated that U-s protection is unnecessary for the successful synthesis of thiouracil-containing PNA. The new 2-thiothymine (T-s) PNA monomer has also been prepared and incorporated into an oligomer and its binding to complementary PNA evaluated.
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