期刊
JOURNAL OF NEUROSURGERY
卷 133, 期 5, 页码 1605-1611出版社
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2019.7.JNS191254
关键词
deep brain stimulation; quantitative susceptibility mapping; globus pallidus internus; Parkinson's disease; electrode placement; functional neurosurgery; diagnostic technique
资金
- Natural Science Foundation of China [81471387, 81801652]
- Science and Technology Commission of Shanghai Municipality [17411952700]
- Shanghai Sailing Program [18YF1414700]
OBJECTIVE: The goal of this study was to demonstrate the use of quantitative susceptibility mapping (QSM)-based images to precisely localize the globus pallidus internus (GPi) for deep brain stimulation (DBS) planning and to enhance postsurgical visualization of the DBS lead positions. METHODS: Presurgical T1-weighted (T1w), T2-weighted (T2w), and QSM images as well as postsurgical CT images were obtained in 29 patients with Parkinson's disease. To enhance the contrast within the GP, a hybrid contrast was created by linearly combining T1w and QSM images. Contrast-to-noise ratios (CNRs) of the GPi on T1w, T2w, QSM, and hybrid images were compared. The CNR differences were tested using the 1-way ANOVA method. The visualization of the DBS lead position was demonstrated by merging the postsurgical CT with presurgical MR images. RESULTS: The hybrid images yield the best CNRs for GPi depiction and the visualization of the postsurgical DBS lead position was significantly improved. CONCLUSIONS: QSM-based images allow for confident localization of borders of the GPi that is superior to T1w and T2w images. High-contrast hybrid images can be used for precisely directed DBS targeting, e.g., GPi DBS for the treatment of advanced Parkinson's disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据