期刊
JOURNAL OF NATURAL PRODUCTS
卷 82, 期 11, 页码 3025-3032出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.9b00567
关键词
-
资金
- National Research Foundation of Korea (NRF) - Korean government (MSIT) [NRF2018R1C1B5083127]
- Development of New Chemical Medical Measurement Standard Technology - Korea Research Institute of Standards and Science [KRISS - 2019 - GP2019-0009]
Chromatographic purification of a methanol extract of the roots of Lespedeza bicolor led to the isolation of four new pterocarpans (1-4), two new coumestans (6 and 7), two new arylbenzofurans (8 and 9), and the known pterocarpan 1-methoxyerythrabyssin II (5). Their structures were identified using NMR spectroscopy, UV spectroscopy, and mass spectrometry. Cytotoxicity assays showed that compounds 1-9 exerted antiproliferative effects on blood cancer cells. Of these compounds, 1 and 6 induced mitochondrial depolarization and induced apoptosis in Jurkat cells. These compounds promoted cell death by inducing cell-cycle arrest at the G1 stage, reducing levels of BCL2, and increasing cleavage of PARP-1. These findings indicate that 1 and 6 are possible lead compounds for the treatment of human leukemia cells via intracellular signaling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据