期刊
BIOORGANIC CHEMISTRY
卷 69, 期 -, 页码 1-6出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2016.09.003
关键词
1 '-Homonucleosides; 1,2,3-Triazole; Antifungal activity; Azide-enolate cycloaddition
资金
- SIEA-UAEMex [3804/2014/CID]
- CONACYT-Mexico [227581, 273644]
The first report of 1'-homo-N-1,2,3-triazol-bicyclic carbonucleosides (7a and 7b) is described herein. Azide-enolate (3+2) cycloaddition afforded the synthesis of this novel type of compound. Antifungal activity was evaluated in vitro against four filamentous fungi (Aspergillus fumigatus, Trichosporon cutaneum, Rhizopus oryzae and Mucor hiemalis) as well as nine species of Candida spp. as yeast specimens. These pre-clinical studies suggest that compounds 7a and 7b are promising candidates for complementary biological studies due to their good activity against Candida spp. (C) 2016 Elsevier Inc. All rights reserved.
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