期刊
JOURNAL OF MOLECULAR ENDOCRINOLOGY
卷 63, 期 3, 页码 R73-R80出版社
BIOSCIENTIFICA LTD
DOI: 10.1530/JME-19-0152
关键词
FSH; menopause; osteoporosis; obesity; bone
资金
- National Institutes of Health [R01 AG40132, R01 AR67066, R01 DK113627, U19 AG60917]
FSH has a primary function in procreation, wherein it induces estrogen production in females and regulates spermatogenesis in males. However, in line with our discoveries over the past decade of non-unitary functions of pituitary hormones, we and others have described hitherto uncharacterized functions of FSH. Through high-affinity receptors, some of which are variants of the ovarian FSH receptor (FSHR), FSH regulates bone mass, adipose tissue function, energy metabolism, and cholesterol production in both sexes. These newly described actions of FSH may indeed be relevant to the pathogenesis of bone loss, dysregulated energy homeostasis, and disordered lipid metabolism that accompany the menopause in females and aging in both genders. We are therefore excited about the possibility of modulating circulating FSH levels toward a therapeutic benefit for a host of age-associated diseases, including osteoporosis, obesity and dyslipidemia, among other future possibilities.
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