期刊
JOURNAL OF MOLECULAR BIOLOGY
卷 432, 期 3, 页码 638-642出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jmb.2019.09.026
关键词
Hi-C; Topologically associating domains; Computational biology; 3D genome; Gene regulation
资金
- European Research Council [637587]
- Vidi grant from the Netherlands Scientific Organization (NWO) [016.16.316]
- Dutch Cancer Society
- European Research Council (ERC) [637587] Funding Source: European Research Council (ERC)
Developments in proximity ligation methods and sequencing technologies have provided high-resolution views of the organization of the genome inside the nucleus. A prominent feature of Hi-C maps is regions of increased self-interaction called topologically associating domains (TADs). Despite the strong evolutionary conservation and clear link with gene expression, the exact role of TADs and even their definition remains debatable. Here, I review the discovery of TADs, how they are commonly identified, and the mechanisms that lead to their formation. Furthermore, I discuss recent results that have created a more nuanced view of the role of TADs in the regulation of genes. In light of this, I propose that when we define TADs, we also consider the mechanisms that shape them. (C) 2019 Elsevier Ltd. All rights reserved.
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