期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 26, 期 20, 页码 4966-4969出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.09.007
关键词
Nephthea columnaris; 19-Norsterol; Columnaristerol; Cytotoxicity
资金
- National Museum of Marine Biology and Aquarium
- National Dong Hwa University
- National Sun Yat-sen University
- Ministry of Science and Technology [MOST 105-2325-B-291-001, 104-2320-B-291-001-MY3]
- National Health Research Institutes [NHRI-EX103-10241BI]
- Chinese Medicine Research Center
- China Medical University (Ministry of Education, Aim for the Top University Plan), Taiwan
Columnaristerol A (1), a rare natural 19-norsterol possessing a 10 beta-hydroxy group was isolated from the Formosan octocoral Nephthea columnaris, and its structure was elucidated by spectroscopic methods. Sterol 1 was found to be a cytotoxic agent that exhibited in vitro moderate cytotoxic activity against MOLT-4 and SUP-T1 human leukemia-lymphoma cell lines. (C) 2016 Elsevier Ltd. All rights reserved.
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