期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 26, 期 12, 页码 2788-2794出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.04.066
关键词
Morus alba; Moraceae; 2-Arylbenzofuran; Geranylated stilbene; Pancreatic lipase
资金
- Gyeongsanbuk-do Forest Environment Research Institute, Korea
Detailed phytochemical investigation from the root bark of Morus alba resulted in the isolation of eleven new compounds, including seven 2-arylbenzofuran derivatives (morusalfurans A-G), three flavonoids (morusalnols A-C), and one geranylated stilbene (morusibene A), as well as 22 known compounds. The structures of the identified compounds were elucidated based on a comprehensive analysis of spectroscopic data and Mosher's method. Compounds 2, 3, 6-8, 11, 23, 24, and 29 showed potent inhibition of PL in comparison with the positive control treatment (orlistat, IC50 = 0.012 mu M), with IC50 values ranging from 0.09 to 0.92 mu M. (C) 2016 Elsevier Ltd. All rights reserved.
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