期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 26, 期 20, 页码 5029-5031出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.08.093
关键词
Marine algicolous fungi; Trichoderma citrinoviride; Norditerpene; Citrinovirin
资金
- National Natural Science Foundation of China [31670355]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA11020702]
Citrinovirin (1), a novel norditerpene with an unprecedented carbon skeleton along with three known compounds, cyclonerodiol (2), 3-(2-hydroxypropyl)-4-(hexa-2E, 4E-dien-6-yl)furan-2(5H)-one (3), and 5-hydroxy-3-hydroxymethyl-2-methyl-7-methoxychromone (4), was isolated from the culture of a marine brown alga-endophytic strain (cf-27) of Trichoderma citrinoviride. The structure and relative configuration of 1 were identified by spectroscopic methods, including 1D/2D NMR and MS. Its absolute configuration was established by analysis of ECD spectrum, aided by quantum chemical calculations. A plausible biogenetic pathway is proposed for 1, and it was evaluated to be active against Staphylococcus aureus. (C) 2016 Elsevier Ltd. All rights reserved.
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