期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 26, 期 6, 页码 1639-1644出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.01.055
关键词
Indole 2-carboxylic acid; 1,2,3-Triazoles; Antibacterial; Anticancer; DNA-cleavage activity
资金
- council of scientific and industrial research-University Grant Commission (CSIR-UGC) New Delhi
A series of new indole-2-carboxylic acid derived mono and bis 1,4-disubstituted 1,2,3 triazoles (I-1-I-6 and I-7-I-12) were synthesized and screened for their anticancer (in vitro and in vivo), antibacterial, and DNA cleavage activities. All the synthesized compounds were characterized by spectral studies. The in vitro anticancer screening results revealed that compound I-12 has registered potential activity against MCF-7, HeLa and HEK293 as compared with the standard reference drug Cisplatin. Remaining compounds have exhibited moderate to good activity against three cancer cell lines. The antibacterial activity screening results revealed that compounds, I-6 and I-12 have registered excellent inhibition against Escherichia coli and Bacillus subtilis in comparison with the standard drug Streptomycin. Compounds I-2 and I-11 have partially cleaved the DNA at 100 lgmL(-1) concentration. (C) 2016 Elsevier Ltd. All rights reserved.
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