期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 26, 期 15, 页码 3577-3580出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.06.018
关键词
Flavones; Acacetin; Synthesis; Fries rearrangement; Atrial fibrillation; Catalysis
资金
- RISE (Research Initiative for Summer Engagement) grant from Office of the Vice President for Research at the University of South Carolina
Acacetin, a O-methylated bioflavonoid isolated from the traditional Chinese medicine Xuelianhua (Saussurea tridactyla), is a promising orally effective atrium-selective antiarrhythmic agent for the treatment of atrial fibrillation (AF). Here we describe an efficient two-component method for the synthesis of acacetin and its derivatives. (C) 2016 Elsevier Ltd. All rights reserved.
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