期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 26, 期 13, 页码 3192-3194出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.04.078
关键词
Aromatase inhibitor; Imidazole; Anticancer agents; Synthesis; Sulfonamide
资金
- University 'G. d'Annunzio' of Chieti local grants
- Emilia Romagna Start-Up grant of the Italian Association for Cancer Research (AIRC) Start-Up grants [6266, 6108]
The most frequently used treatment for hormone receptor positive breast cancer in post-menopausal women are aromatase inhibitors. In order to develop new aromatase inhibitors, we designed and synthesized new imidazolylmethylpiperidine sulfonamides using the structure of the previously identified aromatase inhibitor SYN 20028567 as starting lead. By this approach, three new aromatase inhibitors with IC50 values that are similar to that of letrozole and SYN 20028567 were identified. (C) 2016 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据