Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols

One therapeutic approach for Alzheimer's disease is to inhibit the cleavage of the amyloid precursor protein (APP) by gamma-secretase. At the beginning of a series of studies from our laboratories, a series of novel gamma-amino alcohols (1) were found to possess c-secretase inhibitory activity and Notch-sparing effects. A new one-pot synthesis of gamma-amino alcohols and the structure-activity relationship (SAR) of these analogs will be discussed. (C) 2016 Elsevier Ltd. All rights reserved.