期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 199, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2019.110793
关键词
Photodynamic therapy; DNA binding; Confocal microscopy; Phthalocyanine; Singlet oxygen generation
资金
- NSERC
- CFI
- Minnesota Supercomputing Institute
- University of Manitoba
- WestGrid Canada
Two cationic zinc phthalocyanines have been tested for their interactions with several DNA secondary structures. Despite different aggregation properties, both phthalocyanines bind to DNA in monomeric forms. The strong photodynamic activity of phthalocyanines was demonstrated by in vitro experiments and correlate well with high singlet oxygen yields determined experimentally with 1,3-diphenylisobenzofurane. Both phthalocyanines accumulate in the cell cytoplasm prior to radiation; however, only the octacationic photosensitizer was observed in the cell nuclei after irradiation.
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