期刊
JOURNAL OF INFECTIOUS DISEASES
卷 221, 期 6, 页码 878-881出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiz527
关键词
herpesviruses; iciHHV-6; integration; rs73185306 C/T SNP; HHV-6A/B; HHV-6
资金
- Heart and Stroke Foundation of Canada
- Canadian Institutes of Health Research
Approximately 1% of people worldwide carry a copy of the human herpesvirus 6A or 6B (HHV-6A/B) in every cell of their body. This condition is referred to as inherited chromosomally integrated HHV-6A/B (iciHHV-6A/B). The mechanisms leading to iciHHV-6A/B chromosomal integration are yet to be identified. A recent report suggested that the rs73185306 C/T single-nucleotide polymorphism (SNP) represents a favorable predisposing factor leading to HHV-6A/B integration. After genotype analysis of an independent cohort (N = 11 967), we report no association between the rs73185306 C/T SNP and HHV-6A/B chromosomal integration (odds ratio, 0.90 [95% confidence interval, .54-1.51]; P = .69).
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