期刊
JOURNAL OF INFECTION
卷 80, 期 1, 页码 116-120出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.jinf.2019.09.019
关键词
Asymptomatic Leishmania infection; Blood donors; Western Blot; PCR
资金
- Lab P3 funds from the Emilia-Romagna Region (Italy)
- RFO 2010-2016 funds from the University of Bologna
Objectives: Human leishmaniasis can be severe and fatal, yet in the Mediterranean region only a small percentage of infections progress to clinical disease. We evaluated the percentage of asymptomatic Leishmania infection in the Bologna province, northeastern Italy. Methods: We examined the presence of specific antibodies by Western Blot (WB) and parasitic DNA by real time PCR in peripheral blood of 240 blood donors residing in the Bologna province. Results: Anti-Leishmania IgG were detected by WB in 27 subjects (11.2%, 95% CI 7%-15%), while Leishmania kinetoplast DNA was detected in peripheral blood specimens of 4 out of 240 donors (1.7%, 95% CI 0.2%3.2%). Overall, the prevalence of Leishmania infection in the blood donor cohort was 12.5%, thus indicating an elevated cumulative exposure to the Leishmania parasite in the examined municipality. Conclusions: Our results suggest that a surveillance system for monitoring Leishmania infection in blood donors and/or strategies of protozoan inactivation in whole blood should be taken into consideration in areas with circulation of the Leishmania parasite. (C) 2019 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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