期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 26, 期 2, 页码 622-625出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2015.11.064
关键词
Nucleic acid-based therapeutics; Prodrug; Protecting group; Glutathione
资金
- Ministry of Education, Culture, Sports, Science, and Technology, Japan
- Takahashi Industrial and Economic Research Foundation
We have examined substituted benzyl protecting groups for the phosphodiester in oligodeoxyribonucleotides. Stability of the protecting groups in buffer and rates of deprotection by glutathione (GSH) were strongly influenced by benzyl ring substituents. (C) 2015 Elsevier Ltd. All rights reserved.
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