期刊
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY
卷 33, 期 5, 页码 256-264出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0891988719882104
关键词
health-related quality of life; somatic comorbidities; cognitive functioning; neuropsychiatric symptoms; subjective cognitive decline; mild cognitive impairment
资金
- Alzheimer Nederland [20083494]
Objective: To identify determinants within 3 different domains (ie, somatic comorbidities, cognitive functioning, and neuropsychiatric symptoms [NPS]) of health-related quality of life (HRQoL) over time in memory clinic patients without dementia. Methods: This longitudinal multicenter cohort study with a 3-year observation period recruited 315 individuals (age: 69.8 +/- 8.6, 64.4% males, Mini-Mental State Examination score 26.9 +/- 2.6). A multivariable explanatory model was built using linear mixed effects models (forward selection per domain) to select determinants for self-perceived HRQoL over time, as measured by the EuroQoL-5D visual analogue scale (EQ VAS). Results: Mean HRQoL at study entry was 69.4 +/- 15.6. The presence of agitation, appetite and eating abnormalities, and eyes/ears/nose (ie, sensory impairment) comorbidities were associated with a change in HRQoL over time. Agitation was most strongly associated with HRQoL over time. Conclusions: The association of somatic comorbidities and NPS in memory clinic patients with course of HRQoL shows that these should receive more awareness, detection, and monitoring by clinicians.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据