期刊
JOURNAL OF GENERAL VIROLOGY
卷 100, 期 12, 页码 1695-1700出版社
MICROBIOLOGY SOC
DOI: 10.1099/jgv.0.001333
关键词
cytomegalovirus; monocyte; chemokine; salivary glands
资金
- National Health and Medical Research Council of Australia [1122070, 1140169]
- Australian Research Council [DP190101851]
- Queensland Health
- National Health and Medical Research Council of Australia [1140169] Funding Source: NHMRC
Cytomegaloviruses (CMVs) use myeloid cells to move within their hosts. Murine CMV (MCMV) colonizes the salivary glands for long-term shedding, and reaches them via CD11c(+) infected cells. A need to recruit patrolling monocytes for systemic spread has been proposed, based on poor salivary gland infection in fractalkine receptor (CX3CR1)-deficient mice. We found no significant CX3CR1 dependence of salivary gland infection. CCL2 and the viral m131/m129 chemokine homologue were also redundant for acute MCMV spread, arguing against a need for inflammation or infection to recruit additional monocytes to the entry site. M131/m129 promoted salivary gland infection, but only after the initial seeding of infected cells to this site. Our data support the idea that MCMV disseminates by infecting and mobilizing tissue-resident dendritic cells.
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