期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 26, 期 19, 页码 4705-4708出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.08.047
关键词
beta-Carboline; DNA; Eudistomin U; UV-Vis; Thermal denaturation; Circular dichroism; Differential scanning calorimetry
资金
- Providence College
- Rhode Island Foundation Medical Research Funds
- Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health [P20GM103430]
Eudistomin U is a member of the beta-carboline class of heterocyclic amine-containing molecules that are capable of binding to DNA. The structure of eudistomin U is unique since it contains an indole ring at the 1-position of the pyridine ring. While simple beta-carbolines are reported to intercalate DNA, an examination of the mode of binding of eudistomin U has been lacking. We report preliminary spectroscopic (UV-Vis, thermal denaturation, CD) and calorimetric (DSC) data on the binding of eudistomin U to DNA, which suggest that eudistomin U binds weakly according to a mechanism that is more complicated than other members of its class. (C) 2016 Elsevier Ltd. All rights reserved.
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