期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 216, 期 12, 页码 2689-2700出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20182244
关键词
-
资金
- Novo Nordisk Foundation [14052]
- Fonden til laegevidenskabens Fremme [16-248]
- HorslevFonden [203866]
- Augustinus Fonden [15-1374]
- Aage og Johanne Louis-Hansens Fond [L-153, 18-2B-2769]
- Civilingenior Frode V Nyegaard og Hustrus Fond
- Dagmar Marshalls Fond
- Knud Hojgaards Fond [48-780]
- Crohn's and Colitis Foundation of America
- Jill Roberts Institute
- National Institutes of Health [DK113136, AI137157, AI074878, AI095466, AI095608, AI102942]
- Burroughs Wellcome Fund
- Cure for IBD
- Rosanne H. Silbermann Foundation
Host-microbiota interactions are critical in regulating mammalian health and disease. In addition to bacteria, parasites, and viruses, beneficial communities of fungi (the mycobiome) are important modulators of immune- and tissue-homeostasis. Chitin is a major component of the fungal cell wall, and fibrinogen C containing domain 1 (FIBCD1) is a chitin-binding protein; however, the role of this molecule in influencing host-mycobiome interactions in vivo has never been examined. Here, we identify direct binding of FIBCD1 to intestinal-derived fungi and demonstrate that epithelial-specific expression of FIBCD1 results in significantly reduced fungal colonization and amelioration of fungal-driven intestinal inflammation. Collectively, these results identify FIBCD1 as a previously unrecognized microbial pattern recognition receptor through which intestinal epithelial cells can recognize and control fungal colonization, limit fungal dysbiosis, and dampen intestinal inflammation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据