期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 26, 期 4, 页码 1305-1309出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.01.012
关键词
Fluoroquinolone; Pseudomonas; Mucoid; Biofilm; Antibacterial
资金
- Marshall University School of Pharmacy FRS Grant Program
- Office of Experiential Learning
- National Institutes of Health (NIH) [UL1TR000117]
- NIH [P20GM103434]
Pseudomonas aeruginosa is a common biofilm-forming bacterial pathogen implicated in diseases of the lungs. The extracellular polymeric substances (EPS) of respiratory Pseudomonas biofilms are largely comprised of anionic molecules such as rhamnolipids and alginate that promote a mucoid phenotype. In this Letter, we examine the ability of negatively-charged fluoroquinolones to transverse the EPS and inhibit the growth of mucoid P. aeruginosa. Anionic fluoroquinolones were further compared with standard antibiotics via a novel microdiffusion assay to evaluate drug penetration through pseudomonal alginate and respiratory mucus from a patient with cystic fibrosis. (C) 2016 Elsevier Ltd. All rights reserved.
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