4.5 Article

Antimycobacterial activity of new N1-[1-[1-aryl-3-[4-(1H-imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives

期刊

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 26, 期 14, 页码 3287-3290

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2016.05.053

关键词

Antimycobacterial activity; Pyridine-2-carboxamidrazone derivatives; Mycobacteria other than tuberculosis (MOTT)

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N-1-[1-[1-aryl-3-[4-(1H-imidazol-1-yl)phenyl]-3-oxo]propyl]-pyridine-2-carboxamidrazone derivatives were design, synthesized and tested for their in vitro antimycobacterial activity. The new compounds showed a moderate antimycobacterial activity against the tested strain of Mycobacterium tuberculosis H37Ra and a significant antimycobacterial activity against several mycobacteria other than tuberculosis strains. (C) 2016 Elsevier Ltd. All rights reserved.

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