Effect of B-site doping on Sr2PdO3 perovskite catalyst activity for non-enzymatic determination of glucose in biological fluids

For the first time, a sensitive, selective and durable non-enzymatic glucose electrode was introduced based on Au-doped strontium palladium nano-perovskite modified graphite sensor. The effect of the metal dopant type in B site of Sr2PdO3 perovskite; (M: Ni2+, Cu2+, Au3+, and Pt2+) was evaluated. Sr2Pd0.7Au0.3O3 modified graphite sensor with molar concentration of dopant 0.3 showed the highest electro-catalytic activity for non-enzymatic glucose sensing. The high catalytic activity of Sr2Pd0.7Au0.3O3 is attributed to the inclusion of highly conductive Au3+ dopant, generation of extra oxygen vacancies, enhancement of electronic and ionic conductivity, and stabilization of the orthorhombic perovskite structure. The proposed non-enzymatic glucose sensor offered high performance in terms of amperometric measurements in real serum samples, wide concentration range; 0.2 mu M-100 mu M, high sensitivity; 1.44 x 10(4) mu A mM(-1) cm(-2), low detection limit; 2.11 nM and anti-interference ability. Also, this sensor offered long term stability and good shelf time up to one month with repetitive usage.