Improving the throughput of batch photochemical reactions using flow: Dual photoredox and nickel catalysis in flow for C(sp2)-C(sp3) cross-coupling

We report herein the transfer of dual photoredox and nickel catalysis for C(sp(2))-C(sp(3)) cross coupling form batch to flow. This new procedure clearly improves the scalability of the previous batch reaction by the reactor's size and operating time reduction, and allows the preparation of interesting compounds for drug discovery in multigram amounts. (C) 2017 The Authors. Published by Elsevier Ltd.