4.7 Article

Improving the throughput of batch photochemical reactions using flow: Dual photoredox and nickel catalysis in flow for C(sp2)-C(sp3) cross-coupling

期刊

BIOORGANIC & MEDICINAL CHEMISTRY
卷 25, 期 23, 页码 6190-6196

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2016.12.041

关键词

Photoredox; Dual catalysis; Flow chemistry; C(sp(2))-C(sp(3)) cross-coupling; Medicinal chemistry

资金

  1. European Union [641861]
  2. Marie Curie Actions (MSCA) [641861] Funding Source: Marie Curie Actions (MSCA)

向作者/读者索取更多资源

We report herein the transfer of dual photoredox and nickel catalysis for C(sp(2))-C(sp(3)) cross coupling form batch to flow. This new procedure clearly improves the scalability of the previous batch reaction by the reactor's size and operating time reduction, and allows the preparation of interesting compounds for drug discovery in multigram amounts. (C) 2017 The Authors. Published by Elsevier Ltd.

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