期刊
JOURNAL OF CONTROLLED RELEASE
卷 313, 期 -, 页码 80-95出版社
ELSEVIER
DOI: 10.1016/j.jconrel.2019.10.007
关键词
Nanoparticles; Physicochemical characterization; Biomaterials; MicroRNA delivery and release; Personalized medicine
资金
- MIT-POLITO grant BIOMODE - Compagnia di San Paolo
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme (BIORECAR) [772168]
- National Research Foundation, Prime Minister's Office, Singapore
- Agency for Science, Technology and Research (A*STAR)
- National Science Foundation, Science and Technology Center on Emergent Behaviors of Integrated Cellular Systems [CBET-0939511]
- US National Cancer Institute [U01 CA214381-01]
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [658665]
- joint Doctorate of Bioengineering and Medical-Surgical Sciences of University of Turin
- Politecnico di Torino
- Marie Curie Actions (MSCA) [658665] Funding Source: Marie Curie Actions (MSCA)
MicroRNAs (miRNAs) are attracting a growing interest in the scientific community due to their central role in the etiology of major diseases. On the other hand, nanoparticle carriers offer unprecedented opportunities for cell specific controlled delivery of miRNAs for therapeutic purposes. This review critically discusses the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of cancer and neurodegenerative disorders and for tissue regeneration. A fresh perspective is presented on the design and characterization of nanocarriers to accelerate translation from basic research to clinical application of miRNA-nanoparticles. Main challenges in the engineering of miRNA-loaded nanoparticles are discussed, and key application examples are highlighted to underline their therapeutic potential for effective and personalized medicine.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据