期刊
JOURNAL OF COLLOID AND INTERFACE SCIENCE
卷 555, 期 -, 页码 145-156出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcis.2019.07.045
关键词
Zwitterionic hydrogel; Anti-biofouling; Resin; Hemocompatibility; Protein-bound toxin
资金
- National Natural Science Funds for Innovation Research Groups [21621004]
- National Natural Science Funds for Excellent Young Scholars [21422605]
- Qingdao National Laboratory for Marine Science and Technology [QNLM2016ORP0407]
- Tianjin Natural Science Foundation [18JCYBJC29500]
- China Postdoctoral Science Foundation [2019M651041]
Resin hemoperfusion is a life-saving treatment for drug intoxication or hepatic failure of patients. However, current resin adsorbents exhibit a limited hemocompatibility or low adsorption efficiency, representing a major roadblock to successful clinical applications. In this work, we developed a hemocompatible and effective hemoadsorbent based on polystyrene resin (H103) microparticles encapsulated in anti-biofouling zwitterionic poly(carboxybetaine) (PCB) hydrogels. Apart from a strong mechanical stability, this PCB-based adsorbent (PCB-H103) exhibited excellent hemocompatibility (hemolysis ratio was similar to 0.64%), which was attributed to the anti-biofouling property of PCB hydrogel. In addition, it can efficiently adsorb both small and middle molecular weight molecules in phosphate-buffered saline, and the efficiencies were significantly higher than poly(ethylene glycol) methacrylate-based and poly (2-hydroxyethyl methacrylate)-based adsorbent counterparts, indicating the favorable permeability of PCB hydrogel coating. More importantly, PCB-H103 could effectively remove protein-bound toxins including phenol red and bilirubin in bovine serum albumin solution or even in 100% fetal bovine serum (FBS). In 100% FBS, the adsorption capacity of PCB-H103 towards bilirubin was 8.3 times higher than that of pristine clinical-scale resin beads. Findings in this work may provide a new strategy for the development of modern resin hemoperfusion technology. (C) 2019 Elsevier Inc. All rights reserved.
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