期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 24, 期 14, 页码 3166-3173出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2016.05.044
关键词
Flavonoids; Dithiolium salts; Dithiocarbamates; Antibacterial activity; Aminals
资金
- Romanian National Authority for Scientific Research, CNDI-UEFISCDI [51/2012]
A series of halogen-substituted tricyclic flavonoids containing a 1,3-dithiol-2-ylium moiety has been synthesized from the corresponding 3-dithiocarbamic flavanones. The influence of halogen substituents on the antibacterial properties of the tricyclic flavonoids has been investigated against Staphylococcus aureus and Escherichia coli. On going from fluorine to iodine, these compounds exhibit good to excellent inhibitory properties against both Gram-positive and Gram-negative pathogens. These results suggest that size is the main factor for the change in potency rather than polarity/electronics. (C) 2016 Elsevier Ltd. All rights reserved.
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